Treatment For Unresponsive MS Shows Promise

Researchers have announced results of the study that may provide a possible treatment avenue for unresponsive forms of MS. The study was conducted by the Multiple Sclerosis Research Center of New York (MSRCNY) in collaboration with the International Multiple Sclerosis Management Practice (IMSMP). It dealt with how Intrathecal Methotrexate Treatment may affect MS. The said study is published in Journal of Neurology.

The study involved an open label, review case study of MS patients and intrathecal methotrexate or ITMTX. It followed 87 patients with secondary progressive MS and 34 patients with primary-progressive type of MS. The groups were given about 8 treatments of ITMTX and a one year follow-up after having the last treatment. The patients also underwent the Expanded Disability Status Scale(EDSS) evaluations.

After the study period, the evaluations showed stability or improvement in 89 percent of patients belonging to the secondary-progressive MS and with 82 percent from the primary-progressive MS patients. Post-treatments scores also improved for those within the first group while no significant improvement was shown among the 2nd group in terms of post-treatment scores. This shows that an MS treatment using ITMTX may have a beneficial role in treating a progressive form of the said disease

According to Dr. Saud A. Sadiq, Director of the IMSMP/MSRCNY and the lead author of the study, “We have opened an avenue of treatment for an otherwise untreatable form of MS. This is exciting news because it’s the first time a treatment has been shown to be effective in the late stages/progressive forms of MS.”


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