Research Links Rogue Protein To MS

shutterstock_72572533A team of researchers have identified a rogue protein linked to multiple sclerosis, a disease that causes the body’s own immune system to attack the central nervous system. They believe that this discovery could lead to a better understanding of diseases like MS and help develop new treatments for other similar neurodegenerative diseases.

Scientists from the University of Surrey, University of Texas Medical Center and PrioCam Laboratories were also able to produce unique molecules called antibodies to battle against these rogue proteins. They have previously known that rogue proteins are one of the main causes of brain damage in diseases such as Parkinson’s, Alzheimer’s and Creutzfeldt-Jakob disease.

The researchers discovered that the antibodies were able to recognize rogue proteins in Creutzfeldt-Jakob disease as well as other molecules linked to other neurodegenerative diseases. They moved to try and investigate if rogue proteins were present in the brain tissue and spinal fluid of patients suffering from MS. The scientists were able to conclude that the disease may be caused by a type of protein that has permanently taken a rogue state.

According to Dr. Mourad Tayebi, one of the senior researchers from the University of Surrey, “Multiple sclerosis represents a substantial health burden, affecting the quality of life of many people. Our discovery proposes a new and alternative way to conduct research into multiple sclerosis, by, for the first time, identifying a clear link to other neurodegenerative diseases. The results are important in redefining the molecular and cellular make-up of these diseases, and provide an important milestone in the quest for a laboratory test and an effective cure.”

Dr. Monique David, a researcher from PrioCam and a senior co-author of the said study further added, “Our research indicates that rogue proteins share a common structure and may share similar pathogenic mechanisms. This study consistently and reproducibly links the presence of abnormally shaped proteins to multiple sclerosis.”

The study findings were published in the journal Frontiers in Neurology.

Source: Medical News Today

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