HPV Vaccine Not Linked To Increased MS Risk

shutterstock_147129197There were some recent reports that seem to associate human papillomavirus or HPV vaccination to the development of multiple sclerosis and other demyelinating diseases. But a recent follow-up review of girls and women in Sweden and Denmark who received such a vaccination did not indicate any increased risk of MS. The findings of the study are found in the January 6 issue of the journal JAMA.

Since the approval of the HPV vaccine in 2006, a total of 175 million doses were known to be distributed worldwide. The introduction of a large-scale vaccination among girls and young women was met with a number of safety concerns. One of them is increasing reports of women developing multiple sclerosis and other demyelinating diseases after HPV vaccination.

In order to investigate the said reports, a team of researchers headed by Nikolai Madrid Scheller, M.B., of the Statens Serum Institut in Copenhagen, Denmark, conducted a study involving Swedish and Danish girls and women with ages from 10 to 44 years old.

The study used nationwide registers to identify the participants of the said study group, collecting information on HPV vaccination and data regarding incidence of MS diagnosis as well as for other demyelinating diseases. The researchers followed up on the target group from 2006 to 2013.

The study involved data collected from 3,983,824 girls and women. Of the total, 789,082 were vaccinated during the study period using a total of 1,927,581 qHPV vaccine doses. During follow-up, the researchers identified 4,322 multiple sclerosis cases and 3,300 cases of other demyelinating diseases. Of the total number, 73 and 90 cases, respectively, occurred within the risk period, which was two years following vaccination. After looking at the collected data, the researchers found no increased risk for multiple sclerosis or other demyelinating diseases associated with the qHPV vaccination.

The authors of the said study noted, “Our study adds to the body of data that support a favorable overall safety profile of the qHPV vaccine and expands on this knowledge by providing comprehensive analyses of multiple sclerosis and other demyelinating diseases. The size of the study and the use of nationwide registry data of unselected populations from Denmark and Sweden allowed adequately powered analyses that are likely generalizable.”

Source: The JAMA Network Journals. (2015, January 6). HPV vaccination not associated with increased risk of multiple sclerosis. ScienceDaily. Retrieved January 8, 2015 from www.sciencedaily.com/releases/2015/01/150106121449.htm

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